Effect of total input fluid volume on the prognosis of patients with craniocerebral injury combined with hypernatremia

Hypernatremia is a common complication following craniocerebral injury and an independent predictor of mortality. To evaluate Association between total input fluid volume and the prognosis of patients with craniocerebral injury combined with hypernatremia. The study retrospectively collected 90 patients with craniocerebral injury combined with hypernatremia. The basic information, clinical data of the first day of hypernatremia occurred, and the average volumes of intravenous fluids, total fluid input and diuretic dosages following 3 days of hypernatremia occurred were gathered. Temperature, heart rate, Glasgow Coma Scale (GCS), chlorine, sodium, ventilation and the amount of Mannitol were correlation with the prognosis of this group of patients. After adjusted the other variables, GCS (B=-0.484, 95% CI=0.409-0.929), ventilation (B=3.489, 95% CI=-1.001-534.162) and total fluid volume (B=0.001, 95% CI=0.998-1.000) became the independent risk factors of the prognosis. The incident of poor prognosis in the group with the amount of 2500~3200 ml within 24 hour is the least (3.1%), while the ones with ≤2500 ml and >3200 ml were 20.5% and 27.4%, respectively. In summary, there was an association between total input fluid volume and the prognosis, which the amount of 2500~3200 ml input fluid within 24 hour is beneficial for the prognosis of patients with craniocerebral injury combined with hypernatremia.